If you have a flexible vice you can move it around in different ways. At the very least you can turn the lock upside down and pick it like that. I don't consider a lock beaten until I can pick it quickly in at least two different alignments.
This is one of the things I like about tensioning tools that stay in the keyway of their own accord (basically, if you take your hand off the tensioning tool, it doesn't move). This decreases the difference between different lock alignments. When tensioning isn't a complex interaction between door, hand, and lock, but instead is just a slight pressure in an arbitrary direction, switching alignments isn't such a big deal for the tensioning side of things at least.