Thickness is typically 0.025"
Titanium this thin shouldn't be impossible to work with. It won't be too easy, but it should still work on an electric grinder for example. I would say though that you will need to water-grind them and probably with an aluminium oxide wheel - See here for example:
http://www.mwponline.co.uk/Features/Grinding_titaniumAlthough it should work, it will be rough on your tools and grinding wheel, so don't expect too long a life from a home-type electric grinder. Unless it is relatively new? - Just these last 5 years or so, I have been seeing some home electric grinders with pretty good wheels already on them. It is an intriguing idea for picks, but it would be for "master" picks - That is they are SO much harder than the brass (or steel) that locks themselves are typically made of, you would have to know not to put too much force into them, or they will damage your locks.
They would make good picks for SPPing, but I wouldn't want to rake a lock with them as it would probably be like scrubbing the inside of the lock with a file.
I personally don't like picks that are too flexible, I prefer stainless steel over spring steel because of that. I have absolutely no idea how titanium would "feel" as a pick, but it does sound like an interesting experiment though
