The picks with handles are almost always better. There may be some situations where you really need the tactile feedback of a pick with no handle but locks like those are way out of my paygrade to begin with
The first set of picks I bought was the PXS-17. The picks are of high-quality, but I spent so much time picking that I got a major blister and then callus on the first knuckle of my middle finger (I use the pencil grip most when picking) because the picks without handles were so thin that they cut into my skin.
I then bought a MPXS-32 and the difference was amazing. The picks were much more comfortable and they didn't dig into my skin.
I highly recommend you get a set with handles!