A complete oversimplification of lock picking a traditional pin tumbler lock involves two parts, tensioning the plug and then manipulating the pins until the lock opens. Most high security features on these types of locks involve special pins that make manipulating them more difficult. So why not make a lock that makes the tensioning much more difficult, if not near-impossible?
I have sketched out a few ideas on paper, and I'm in the process of creating better sketches of each on the computer. I'd like to improve and modify my designs, then create 3D CADs, and eventually 3D print a scaled up working model to continue testing new ideas.
Here is the first of my rough ideas.

The catch bar on the right would keep the plug from turning and keep the pin from being raised as long as tension is placed on the plug. A simple way to defeat this is to raise all the pins up before tensioning, but the catch bar on the left would be forced down and would then catch the plug if you raise the pin too high. Therefore, the only way to tension the plug is to raise the pin to the correct height first and then turn the plug. The pin could be a little smaller than the hole so that the plug will turn just a tiny bit under tension, allowing the catch bar to fully engage. As far as I know, nobody has figured out a way to set all the pins at the proper height before tensioning without using the correct key.
Obviously refining and tweaking needs to happen to make sure that the "sweet spot" where neither catch bar blocks the plug is also at the point where the pins are lined up at the shear line. Plus, once this is developed into a working idea, you could then add other security features like a unique keyway, serrated pins, or split plugs, all of which would just make this lock a nightmare for picking.
I have several other ways I've thought of to stop a lock from being tensioned before picking the pins, and I'm working on drawing them up too. I also need to show other views of this one to better explain it.
Thanks for reading, and I'd love feedback and ideas!